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Dopamine helps nerve cells communicate about movement; without the dopamine, body commands about normal movement are disrupted resulting in Parkinson's disease because the brain does not receive the necessary messages about how and when to move.

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MIRAPEX may be used both as early therapy, without concomitant levodopa, and as an adjunct to levodopa.

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These drugs include pramipexole (Mirapex), and ropinirole (Requip), and apomorphine (Apokyn).

In this study, Mirapex ER tablets, immediate-release pramipexole tablets, or placebo was administered to patients who were also receiving concomitant levodopa.

Angina and MI occurred in some patients within 2 hours of apomorphine dosing; cardiac arrest and sudden death occurred at times unrelated to dosing.

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Coffee drinkers and smokers may have a lower risk of developing Parkinson's (although smoking obviously has other serious health problems).

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