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This medication can't be rated hastily. It can take up to 6 weeks to level off. My first days of Pristiq 50mg were terrible. My first dose at night caused insomnia, jitteriness and dizziness, dilated pupils, nausea, sweaty, and a racing pulse. The following week I felt great with NO ANXIETY! I still felt nauseous however, ate very little(lost 7 lbs), and had a headache daily. The following week my side effects continued ( insomnia & TMJ flare up), but my benefits diminished. My Doctor then increased my dose to 100mg. Since then most of my side effects are gone except the dilated pupils & TMJ issues. I've taken Zoloft(ok) & Lexapro(zombie) in the past. Please give this medicine time before you decide you hate it!

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